Objective: Pregnancy-induced hypertension/preeclampsia (PIH) and fetal growth restriction (FGR) share a common placental origin. The pathologic classification that divides placental
lesions to maternal or fetal origin was compared between these disorders.
Study Design: Placentas from pregnancies that were complicated by PIH, normotensive FGR, or by both (combined) were analyzed, and lesions were classified as those consistent
with maternal under-perfusion and with fetal thromboocclusive disease.
Results: Maternal vascular lesions were more common in the PIH group and combined group (61% and 59%, respectively), compared with the FGR group (16.2%; P < .001), and
villous lesions were more common in the combined group, compared with the FGR and PIH groups (79.5%, 53.5%, and 46.9%, respectively; P = .004). Fetal villous changes
were observed in 16.2% in the FGR group, compared with 3.1% in the PIH group (P = .03), and chronic villitis was 15.2% in the FGR group vs 1.6% in the PIH group (P = .004).
Conclusion: Placental lesions correspond with different clinical presentations.
Michal Kovo 1, Letizia Schreiber 2, Avi Ben-Haroush 3, Suzanna Wand 1
Abraham Golan 1, Jacob Bar 1
Department of Obstetrics & Gynecology 1 and Department of Pathology 2, the Edith Wolfson Medical Center, Holon and the
Rabin Medical Center 3, Petah-Tikva, Sackler Faculty of Medicine , Tel Aviv University, Tel Aviv, Israel