• Home
  • About
    • Our Constitution
    • Chairman’s words
    • Chairman and Board Members
  • Members
    • Become a Member
  • Annual Meetings
    • 1st Annual Meeting – 2010
    • 2nd Annual Meeting – 2011
    • 3rd Annual Meeting – 2012
    • 4th Annual Meeting -2013
    • 5th Annual Meeting- 2014
    • 7th Annual Meeting -2016
    • 8th Annual Meeting -2017
    • 9th Annual Meeting -2018
    • 10th Annual Meeting
    • 11th Annual Meeting
    • 12th Annual Meeting
  • Abstracts
    • Abstracts 2010
    • Abstracts 2011
    • Abstracts 2012
    • Abstracts 2014
    • Abstracts 2015
    • Abstracts 2016
    • Abstracts 2017
    • Abstracts 2018
    • Full Abstract List
  • Organizations
    • ISMFM
    • Israel Medical Association
    • Placenta – The Official Jourmal of IFPA
    • The Israel Fertility Association
    • SMFM
    • International Federation of Placenta Associations
    • The Endocrine Society of Australia
    • Nano Science
    • The Society for Reproductive Biology
    • Australasian Diabetes in Pregnancy Society
    • Society of Theriogenology
    • American College of Theriogenologists
    • The Fetal Medicine Foundation
  • Contact
Menu
  • Home
  • About
    • Our Constitution
    • Chairman’s words
    • Chairman and Board Members
  • Members
    • Become a Member
  • Annual Meetings
    • 1st Annual Meeting – 2010
    • 2nd Annual Meeting – 2011
    • 3rd Annual Meeting – 2012
    • 4th Annual Meeting -2013
    • 5th Annual Meeting- 2014
    • 7th Annual Meeting -2016
    • 8th Annual Meeting -2017
    • 9th Annual Meeting -2018
    • 10th Annual Meeting
    • 11th Annual Meeting
    • 12th Annual Meeting
  • Abstracts
    • Abstracts 2010
    • Abstracts 2011
    • Abstracts 2012
    • Abstracts 2014
    • Abstracts 2015
    • Abstracts 2016
    • Abstracts 2017
    • Abstracts 2018
    • Full Abstract List
  • Organizations
    • ISMFM
    • Israel Medical Association
    • Placenta – The Official Jourmal of IFPA
    • The Israel Fertility Association
    • SMFM
    • International Federation of Placenta Associations
    • The Endocrine Society of Australia
    • Nano Science
    • The Society for Reproductive Biology
    • Australasian Diabetes in Pregnancy Society
    • Society of Theriogenology
    • American College of Theriogenologists
    • The Fetal Medicine Foundation
  • Contact
Facebook
Placental Transfer Of The Insulin Ananlog Glargine In The Ex-vivo Perfused Placental Cotyledon Model
Home ‹ 2010 Abstracts ‹ Placental Transfer Of The Insulin Ananlog Glargine In The Ex-vivo Perfused Placental Cotyledon Model

Objective: Glargine treatment during pregnancy does not appear to be associated with neonatal morbidity, yet the rate and extent of its passage through human placenta is unknown. The aim of the study was to quantify and characterize glargine transfer across the placenta using the ex-vivo placental perfusion model.

Methods: Placentas were obtained from vaginal deliveries or caesarean sections and selected cotyledons were cannulated and dually perfused. Glargine , 50mU/L (n=2) and 200 mU/L (n=1), and a permeability reference marker, antipyrine (50mgr/ml), were added to the maternal circulation. Each perfusion experiment was conducted for 180 minutes while samples were taken from maternal and fetal compartments.

Results: Glargine was not detected in the fetal compartment in any of the 3 complete experimental set-ups. In the maternal compartment the steady state concentration was about 50% lower then the starting concentration.

Conclusions: Insulin glargine does not cross the human placenta, implying its safety use during pregnancy. Reduced maternal steady state concentrations may suggest insulin uptake by the placenta, with possibly further metabolism of the drug by placental enzymes.

Authors:

Michal Kovo 1, Julio Wainstein 2, Zipora Matas 3, Simon Haroutiunian 4
Amnon Hoffman 4, Abraham Golan 1

Department of Obstetrics and Gynecology 1, Diabetes Unit 2 and Department of Biochemical and Endocrine Laboratory 3,
the E. Wolfson Medical Center, Holon, and Sackler School of Medicine, Tel Aviv University, Israel; Department of
Pharmaceutics, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem, Israel

« Previous
Next »
Powered by Netmii and Art + Web
All rights reserved to ISPR -Israel Society for Placental Research
Scroll to top