• Home
  • About
    • Our Constitution
    • Chairman’s words
    • Chairman and Board Members
  • Members
    • Become a Member
  • Annual Meetings
    • 1st Annual Meeting – 2010
    • 2nd Annual Meeting – 2011
    • 3rd Annual Meeting – 2012
    • 4th Annual Meeting -2013
    • 5th Annual Meeting- 2014
    • 7th Annual Meeting -2016
    • 8th Annual Meeting -2017
    • 9th Annual Meeting -2018
    • 10th Annual Meeting
    • 11th Annual Meeting
    • 12th Annual Meeting
  • Abstracts
    • Abstracts 2010
    • Abstracts 2011
    • Abstracts 2012
    • Abstracts 2014
    • Abstracts 2015
    • Abstracts 2016
    • Abstracts 2017
    • Abstracts 2018
    • Full Abstract List
  • Organizations
    • ISMFM
    • Israel Medical Association
    • Placenta – The Official Jourmal of IFPA
    • The Israel Fertility Association
    • SMFM
    • International Federation of Placenta Associations
    • The Endocrine Society of Australia
    • Nano Science
    • The Society for Reproductive Biology
    • Australasian Diabetes in Pregnancy Society
    • Society of Theriogenology
    • American College of Theriogenologists
    • The Fetal Medicine Foundation
  • Contact
Menu
  • Home
  • About
    • Our Constitution
    • Chairman’s words
    • Chairman and Board Members
  • Members
    • Become a Member
  • Annual Meetings
    • 1st Annual Meeting – 2010
    • 2nd Annual Meeting – 2011
    • 3rd Annual Meeting – 2012
    • 4th Annual Meeting -2013
    • 5th Annual Meeting- 2014
    • 7th Annual Meeting -2016
    • 8th Annual Meeting -2017
    • 9th Annual Meeting -2018
    • 10th Annual Meeting
    • 11th Annual Meeting
    • 12th Annual Meeting
  • Abstracts
    • Abstracts 2010
    • Abstracts 2011
    • Abstracts 2012
    • Abstracts 2014
    • Abstracts 2015
    • Abstracts 2016
    • Abstracts 2017
    • Abstracts 2018
    • Full Abstract List
  • Organizations
    • ISMFM
    • Israel Medical Association
    • Placenta – The Official Jourmal of IFPA
    • The Israel Fertility Association
    • SMFM
    • International Federation of Placenta Associations
    • The Endocrine Society of Australia
    • Nano Science
    • The Society for Reproductive Biology
    • Australasian Diabetes in Pregnancy Society
    • Society of Theriogenology
    • American College of Theriogenologists
    • The Fetal Medicine Foundation
  • Contact
Facebook
Placental Secretion Of Interleukin-1 And Interleukin-1 Receptor Antagonist In Preeclampsia; Effect Of Magnesium Sulfate
Home ‹ 2011 Abstracts ‹ Placental Secretion Of Interleukin-1 And Interleukin-1 Receptor Antagonist In Preeclampsia; Effect Of Magnesium Sulfate

Objective: To determine the role of the placenta in controlling the circulatory levels of IL-1β and its natural inhibitor IL-1 receptor antagonist (RA), and to study the effect of magnesium sulfate (MgSO4) on these levels.

Methods: Using an ex-vivo placental perfusion system, human placentas from preeclamptic (n=9) and normotensive (n=6) pregnancies were perfused in presence or absence of MgSO4. Perfusate samples were collected from the maternal and the fetal circulation of the perfusion system, and IL-1β and IL-1RA were examined by ELISA.

Results: Placentas from preeclamptic pregnancies secreted increased levels of IL-1β and IL-1RA into the fetal and the maternal circulations, as compared to normotensive placentas. However, no differences in IL-1β:IL-1RA ratio were detected in the fetal or the maternal circulations. Administration of MgSO4 to preeclamptic placentas resulted in attenuation of the increased secretion of IL-1β in the maternal circulation and of IL-1RA in both the maternal and the fetal circulation. Nevertheless, IL-1β:IL-1RA ratio was not affected by MgSO4. Paradoxically, exposure of normotensive placenta to MgSO4 resulted only in increased levels of IL-1RA in the fetal and the maternal circulations.

Conclusions: Although the increased placental secretion of IL-1β and IL-1RA in preeclampsia, the placenta doesn’t seem to play a critical role in disrupting the balance in maternal IL-1β:IL-1RA ratio in this disorder. Moreover, IL-1β and IL-1RA seem to be not involved in the mechanism of action of MgSO4 in preeclampsia.

Tamar Eshkoli1, Alaa Amash2, Mahmoud Huleihel2,*, Eyal Sheiner1, Gershon Holcberg1,*.

1Department of Obstetrics and Gynecology, Soroka University Medical Center, Beer-Sheva, Israel; 2The Shraga Segal Department of Microbiology and Immunology, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

*These two authors contributed equally to this work

« Previous
Next »
Powered by Netmii and Art + Web
All rights reserved to ISPR -Israel Society for Placental Research
Scroll to top