• Home
  • About
    • Our Constitution
    • Chairman’s words
    • Chairman and Board Members
  • Members
    • Become a Member
  • Annual Meetings
    • 1st Annual Meeting – 2010
    • 2nd Annual Meeting – 2011
    • 3rd Annual Meeting – 2012
    • 4th Annual Meeting -2013
    • 5th Annual Meeting- 2014
    • 7th Annual Meeting -2016
    • 8th Annual Meeting -2017
    • 9th Annual Meeting -2018
    • 10th Annual Meeting
    • 11th Annual Meeting
    • 12th Annual Meeting
  • Abstracts
    • Abstracts 2010
    • Abstracts 2011
    • Abstracts 2012
    • Abstracts 2014
    • Abstracts 2015
    • Abstracts 2016
    • Abstracts 2017
    • Abstracts 2018
    • Full Abstract List
  • Organizations
    • ISMFM
    • Israel Medical Association
    • Placenta – The Official Jourmal of IFPA
    • The Israel Fertility Association
    • SMFM
    • International Federation of Placenta Associations
    • The Endocrine Society of Australia
    • Nano Science
    • The Society for Reproductive Biology
    • Australasian Diabetes in Pregnancy Society
    • Society of Theriogenology
    • American College of Theriogenologists
    • The Fetal Medicine Foundation
  • Contact
Menu
  • Home
  • About
    • Our Constitution
    • Chairman’s words
    • Chairman and Board Members
  • Members
    • Become a Member
  • Annual Meetings
    • 1st Annual Meeting – 2010
    • 2nd Annual Meeting – 2011
    • 3rd Annual Meeting – 2012
    • 4th Annual Meeting -2013
    • 5th Annual Meeting- 2014
    • 7th Annual Meeting -2016
    • 8th Annual Meeting -2017
    • 9th Annual Meeting -2018
    • 10th Annual Meeting
    • 11th Annual Meeting
    • 12th Annual Meeting
  • Abstracts
    • Abstracts 2010
    • Abstracts 2011
    • Abstracts 2012
    • Abstracts 2014
    • Abstracts 2015
    • Abstracts 2016
    • Abstracts 2017
    • Abstracts 2018
    • Full Abstract List
  • Organizations
    • ISMFM
    • Israel Medical Association
    • Placenta – The Official Jourmal of IFPA
    • The Israel Fertility Association
    • SMFM
    • International Federation of Placenta Associations
    • The Endocrine Society of Australia
    • Nano Science
    • The Society for Reproductive Biology
    • Australasian Diabetes in Pregnancy Society
    • Society of Theriogenology
    • American College of Theriogenologists
    • The Fetal Medicine Foundation
  • Contact
Facebook
IMMATURE MYELOID CELLS THAT INFILTRATE THE PLACENTA EXHIBIT UNIQUE ANGIOGENIC PROPERTIES AND ALTERED GENE EXPRESSION
Home ‹ 2014 Abstracts ‹ IMMATURE MYELOID CELLS THAT INFILTRATE THE PLACENTA EXHIBIT UNIQUE ANGIOGENIC PROPERTIES AND ALTERED GENE EXPRESSION

Ofer Fainaru, Shay Hantisteanu, Gili Paz, Niv Pencovich, Mordechai Hallak

Laboratory of Reproductive Immunology, Department of Obstetrics and Gynecology, Hillel Yaffe Medical Center

Angiogenesis is a rate-limiting step in various developmental processes as well as tumor progression and metastasis. Immature myeloid cells (IMCs) play important roles in both physiological and pathological vascularization. We have previously shown that although largely pro-angiogenic, the global transcriptional pattern of IMCs is significantly influenced by the surrounding microenvironment. Differential gene expression can be detected within dormant versus aggressive tumors, as well as in normal angiogenic tissue such as placenta.

In this study we further evaluated the differences between IMCs derived from the mouse placenta, representing normal angiogenesis, and those derived form malignant tumors. We show that in tumors the Ly6Gmed/Ly6Chigh “monocytic” subpopulation of IMCs is enriched compared to Ly6Ghigh/Ly6Cmed “granulocytic” subpopulation within the placenta. This shift corresponds to profound changes in global gene expression between tumor- and placenta derived IMCs. Tumor derived IMCs express genes that are involved in tumor angiogenesis and progression, as well as cell cycle and proliferation. On the other hand, placental IMCs express genes that play role in hematopoiesis and angiogenesis of the reproductive system. Additionally, increased proportion of genes that were highly expressed in placenta IMCs were also highly expressed in dormant compared to aggressive tumors.  Finally, we observed differences in the ability of IMCs isolated from either tumor or placenta to promote angiogenesis in matrigel plugs implanted in mice.

The data suggest that IMCs respond and function differently in malignant versus normal environments. Deciphering the properties of normal vs. pathologic angiogenesis holds promise in the design of new modalities for cancer therapy.

« Previous
Next »
Powered by Netmii and Art + Web
All rights reserved to ISPR -Israel Society for Placental Research
Scroll to top