• Home
  • About
    • Our Constitution
    • Chairman’s words
    • Chairman and Board Members
  • Members
    • Become a Member
  • Annual Meetings
    • 1st Annual Meeting – 2010
    • 2nd Annual Meeting – 2011
    • 3rd Annual Meeting – 2012
    • 4th Annual Meeting -2013
    • 5th Annual Meeting- 2014
    • 7th Annual Meeting -2016
    • 8th Annual Meeting -2017
    • 9th Annual Meeting -2018
    • 10th Annual Meeting
    • 11th Annual Meeting
    • 12th Annual Meeting
  • Abstracts
    • Abstracts 2010
    • Abstracts 2011
    • Abstracts 2012
    • Abstracts 2014
    • Abstracts 2015
    • Abstracts 2016
    • Abstracts 2017
    • Abstracts 2018
    • Full Abstract List
  • Organizations
    • ISMFM
    • Israel Medical Association
    • Placenta – The Official Jourmal of IFPA
    • The Israel Fertility Association
    • SMFM
    • International Federation of Placenta Associations
    • The Endocrine Society of Australia
    • Nano Science
    • The Society for Reproductive Biology
    • Australasian Diabetes in Pregnancy Society
    • Society of Theriogenology
    • American College of Theriogenologists
    • The Fetal Medicine Foundation
  • Contact
Menu
  • Home
  • About
    • Our Constitution
    • Chairman’s words
    • Chairman and Board Members
  • Members
    • Become a Member
  • Annual Meetings
    • 1st Annual Meeting – 2010
    • 2nd Annual Meeting – 2011
    • 3rd Annual Meeting – 2012
    • 4th Annual Meeting -2013
    • 5th Annual Meeting- 2014
    • 7th Annual Meeting -2016
    • 8th Annual Meeting -2017
    • 9th Annual Meeting -2018
    • 10th Annual Meeting
    • 11th Annual Meeting
    • 12th Annual Meeting
  • Abstracts
    • Abstracts 2010
    • Abstracts 2011
    • Abstracts 2012
    • Abstracts 2014
    • Abstracts 2015
    • Abstracts 2016
    • Abstracts 2017
    • Abstracts 2018
    • Full Abstract List
  • Organizations
    • ISMFM
    • Israel Medical Association
    • Placenta – The Official Jourmal of IFPA
    • The Israel Fertility Association
    • SMFM
    • International Federation of Placenta Associations
    • The Endocrine Society of Australia
    • Nano Science
    • The Society for Reproductive Biology
    • Australasian Diabetes in Pregnancy Society
    • Society of Theriogenology
    • American College of Theriogenologists
    • The Fetal Medicine Foundation
  • Contact
Facebook
Are Twin To Twin Transfusion Syndrome And Selective Intra-uterine Growth Restriction A Continuum? – Evidence From A Longitudinal Study Of Circulating Angiogenic Factors
Home ‹ 2012 Abstracts ‹ Are Twin To Twin Transfusion Syndrome And Selective Intra-uterine Growth Restriction A Continuum? – Evidence From A Longitudinal Study Of Circulating Angiogenic Factors

Objective

To determine maternal plasma levels of soluble fms-like tyrosine kinase-1(sFlt-1), placental growth factor (PLGF) and soluble endoglin (sEng) in monochorionic diamniotic (MC/DA) twin pregnancies complicated by twin to twin transfusion syndrome (TTTS) or selective intra-uterine growth restriction (sIUGR).

Methods
A longitudinal cohort study of pregnant women with MC/DA twins who were classified into 3 groups: 1. Uncomplicated MC/DA twins (n=22) 2. TTTS (n=23) and 3. sIUGR (n=15). Maternal plasma samples were obtained between 13-20 and 21-28 weeks of gestation and cord blood samples were collected at delivery. Maternal plasma concentrations of sFlt-1, PLGF and sEng were measured by ELISA.

Results
sFlt-1 and sEng levels were significantly higher in the TTTS at the early (13-20 weeks of gestation) and late (21-28 weeks) second trimester compared to normal monochorionic pregnancies (p<0.01). In contrast, sFlt-1 and sEng levels were significantly higher in the sIUGR group only at the late second trimester (p<0.05). PLGF levels were significantly lower at the early and late second trimester in both TTTS and sIUGR compared to controls (p<0.01). Plasma concentrations of sFlt-1 were significantly higher among TTTS pregnancies compared to sIUGR at the late second trimester (p=0.027). Within TTTS pregnancies who underwent fetoscopic laser ablation, the procedure resulted in elevation of PLGF levels and reduction of sFlt-1 levels. Cord blood analysis revealed significantly higher levels of sFlt-1 in the smaller IUGR twin compared to the normal co-twin.

Conclusions
Monochorionic pregnancies complicated by TTTS and sIUGR are characterized by decreased angiogenic activity. The disparity in severity of the anti-angiogenic state between TTTS and sIUGR suggests that these two conditions may represent a continuum.

 

Authors:

Yoav Yinon, Elad Ben Meir, Boaz Weisz,

Eyal Schiff, Shali Mazaki-Tovi, Shlomo Lipitz

Fetal Medicine Unit, Department of Obstetrics and Gynecology, Sheba Medical Center, Tel-Aviv University

« Previous
Next »
Powered by Netmii and Art + Web
All rights reserved to ISPR -Israel Society for Placental Research
Scroll to top