• Facebook
ISPR
  • Home
  • About
    • Our Constitution
    • Chairman’s words
    • Chairman and Board Members
  • Members
    • Become a Member
  • Annual Meetings
    • 1st Annual Meeting – 2010
    • 2nd Annual Meeting – 2011
    • 3rd Annual Meeting – 2012
    • 4th Annual Meeting -2013
    • 5th Annual Meeting- 2014
    • 7th Annual Meeting -2016
    • 8th Annual Meeting -2017
    • 9th Annual Meeting -2018
    • 10th Annual Meeting
    • 11th Annual Meeting
  • Abstracts
    • Abstracts 2010
    • Abstracts 2011
    • Abstracts 2012
    • Abstracts 2014
    • Abstracts 2015
    • Abstracts 2016
    • Abstracts 2017
    • Abstracts 2018
    • Full Abstract List
  • Organizations
    • ISMFM
    • Israel Medical Association
    • Placenta – The Official Jourmal of IFPA
    • The Israel Fertility Association
    • SMFM
    • International Federation of Placenta Associations
    • The Endocrine Society of Australia
    • Nano Science
    • The Society for Reproductive Biology
    • Australasian Diabetes in Pregnancy Society
    • Society of Theriogenology
    • American College of Theriogenologists
    • The Fetal Medicine Foundation
  • Contact
  • Home
  • About
    • Our Constitution
    • Chairman’s words
    • Chairman and Board Members
  • Members
    • Become a Member
  • Annual Meetings
    • 1st Annual Meeting – 2010
    • 2nd Annual Meeting – 2011
    • 3rd Annual Meeting – 2012
    • 4th Annual Meeting -2013
    • 5th Annual Meeting- 2014
    • 7th Annual Meeting -2016
    • 8th Annual Meeting -2017
    • 9th Annual Meeting -2018
    • 10th Annual Meeting
    • 11th Annual Meeting
  • Abstracts
    • Abstracts 2010
    • Abstracts 2011
    • Abstracts 2012
    • Abstracts 2014
    • Abstracts 2015
    • Abstracts 2016
    • Abstracts 2017
    • Abstracts 2018
    • Full Abstract List
  • Organizations
    • ISMFM
    • Israel Medical Association
    • Placenta – The Official Jourmal of IFPA
    • The Israel Fertility Association
    • SMFM
    • International Federation of Placenta Associations
    • The Endocrine Society of Australia
    • Nano Science
    • The Society for Reproductive Biology
    • Australasian Diabetes in Pregnancy Society
    • Society of Theriogenology
    • American College of Theriogenologists
    • The Fetal Medicine Foundation
  • Contact
ISPR
  • Home
  • About
    • Our Constitution
    • Chairman’s words
    • Chairman and Board Members
  • Members
    • Become a Member
  • Annual Meetings
    • 1st Annual Meeting – 2010
    • 2nd Annual Meeting – 2011
    • 3rd Annual Meeting – 2012
    • 4th Annual Meeting -2013
    • 5th Annual Meeting- 2014
    • 7th Annual Meeting -2016
    • 8th Annual Meeting -2017
    • 9th Annual Meeting -2018
    • 10th Annual Meeting
    • 11th Annual Meeting
  • Abstracts
    • Abstracts 2010
    • Abstracts 2011
    • Abstracts 2012
    • Abstracts 2014
    • Abstracts 2015
    • Abstracts 2016
    • Abstracts 2017
    • Abstracts 2018
    • Full Abstract List
  • Organizations
    • ISMFM
    • Israel Medical Association
    • Placenta – The Official Jourmal of IFPA
    • The Israel Fertility Association
    • SMFM
    • International Federation of Placenta Associations
    • The Endocrine Society of Australia
    • Nano Science
    • The Society for Reproductive Biology
    • Australasian Diabetes in Pregnancy Society
    • Society of Theriogenology
    • American College of Theriogenologists
    • The Fetal Medicine Foundation
  • Contact
  • Home
  • About
    • Our Constitution
    • Chairman’s words
    • Chairman and Board Members
  • Members
    • Become a Member
  • Annual Meetings
    • 1st Annual Meeting – 2010
    • 2nd Annual Meeting – 2011
    • 3rd Annual Meeting – 2012
    • 4th Annual Meeting -2013
    • 5th Annual Meeting- 2014
    • 7th Annual Meeting -2016
    • 8th Annual Meeting -2017
    • 9th Annual Meeting -2018
    • 10th Annual Meeting
    • 11th Annual Meeting
  • Abstracts
    • Abstracts 2010
    • Abstracts 2011
    • Abstracts 2012
    • Abstracts 2014
    • Abstracts 2015
    • Abstracts 2016
    • Abstracts 2017
    • Abstracts 2018
    • Full Abstract List
  • Organizations
    • ISMFM
    • Israel Medical Association
    • Placenta – The Official Jourmal of IFPA
    • The Israel Fertility Association
    • SMFM
    • International Federation of Placenta Associations
    • The Endocrine Society of Australia
    • Nano Science
    • The Society for Reproductive Biology
    • Australasian Diabetes in Pregnancy Society
    • Society of Theriogenology
    • American College of Theriogenologists
    • The Fetal Medicine Foundation
  • Contact
Alterations Of Immature Myeloid Cell Populations In Human Pregnancies Complicated By Preeclampsia
Home ‹ 2010 Abstracts ‹ Alterations Of Immature Myeloid Cell Populations In Human Pregnancies Complicated By Preeclampsia

 Ola Gutzeit, Linoy Segal, Yuval Ginsberg, Ron Beloosesky, Zeev Weiner, Ofer Fainaru

Department of Obstetrics and Gynecology, Rambam Medical Center, Haifa, Israel

 Introduction: Immature myeloid cells (IMCs) are bone marrow-derived cells that normally differentiate into granulocytes, macrophages, and dendritic cells (DCs) but expand in pathological conditions. We have previously shown that IMCs accumulate in the placenta, promote angiogenesis, peak during mid-pregnancy and correlates with neonatal birthweight.

Placental angiogenesis is known to be aberrant in 5-10% of pregnancies leading to intra uterine growth restriction, preeclampsia or other serious pregnancy complications that may lead to maternal and fetal morbidity and mortality.

Study Aim: Our study aimed to investigate IMCs and DCs populations altered in placentas from pregnancies complicated by preeclampsia.

Materials & Methods: Placentas were collected after deliveries from women with pregnancies complicated by preeclampsia (n=8) and normotensive controls (n=12). Placenta samples were enzymatically digested, immunostained and analyzed by flow cytometry. IMCs are defined as CD45+CD33+LIN2−HLADR− cells and DCs are defined as CD45+CD11c+HLADR+ cells (Figure 1). The percentage of IMCs and DCs was calculated of total CD45+ hematopoietic cells in the placenta.

Results: Placentas derived from pregnancies complicated by preeclampsia show a more that two fold increase in the IMC population as compared to normotensive controls (5.30 ± 2.32% vs. 2.48 ± 0.8%, p<0.05) (Figure 2). In contrast, the DC population showed a more than two fold decrease as compared to placentas derived from normotensive controls (4.4 ± 0.88 % vs. 10.03 ± 5.33 %, p<0.05).

Conclusion: The accumulation of proangiogenic IMCs in placentas from pregnancies complicated by preeclampsia along with the decrease in the presence of DCs, may correspond to the hypoxic effects of impaired angiogenesis and the reduced placental perfusion in preeclampsia. These alterations in myeloid cell presence may help elucidate their role in the pathogenesis of preeclampsia and their relevance to aberrant placentation. Moreover, future quantifying of specific myeloid cells from human pregnancy during chorionic villus sampling, or even their presence in maternal blood samples, may provide information about the risk of developing preeclampsia.

« Previous
Next »
Powered by Netmii and Art + Web
All rights reserved to ISPR -Israel Society for Placental Research
Scroll to top